fraxinus excelsior medicinal uses

Gundermann and J. Müller, “Phytodolor®—effects and efficacy of a herbal medicine,”, N.-Y. Exogenous antioxidants primarily include natural as well as synthetic compounds having radical scavenging abilities. Fraxinus plant derivative analogs along with pharmacodynamics and pharmacokinetics may also strengthen future advances. It is also used as a tonic. Serious toxic effects associated with the application of antitoxoplasmosis drugs like sulfadiazine and pyrimethamine arouse the urgent need of safe and effective alternatives. Noteworthy Characteristics. In vitro assessment of hydroxyframoside B isolated from ethanolic extract of stem bark of Fraxinus rhynchophylla provided an approach to decrease obesity via downregulating the pancreatic lipase activity thus restricting the absorption of lipid by pancreas [36]. Smog tolerant. Community herbal monograph on Fraxinus excelsior L. or Fraxinus angustifolia Vahl, folium EMA/HMPC/239271/2011 Page 3/6 Well-established use Traditional use Traditional herbal medicinal product used to increase the amount of urine to achieve flushing of the urinary tract as an adjuvant in minor urinary complaints. This review reveals that Fraxinus plant is a valuable drug candidate with its potential anticarcinogenic, anti-inflammatory, antioxidative, and neuroprotective properties. Fraxinus plant has been accounted for its wide spectrum of biological activities including anticancer, anti-inflammatory, neuroprotective, antioxidant, anticytotoxic, antiaging, antimicrobial, and antihypertensive (Figure 1). Fraxinus excelsior (FE), locally known as “l’ssane l’ousfour”, is a native shrub widely distributed throughout the south-eastern region of Morocco (Tafilalet). Mistletoe extract obtained from host tree Fraxinus showed cytotoxicity against various cancerous cells including chronic myeloid leukemia K562 cells, human multiple myeloma RPMI-8226 cells, and murine leukemia L1210 cells via JNK-1/2, caspase-9, and p38 MAPK activation, Mcl-1 downregulation, and inhibition of PKB and ERK-1/2 phosphorylation. A range of chemical constituents including secoiridoids, phenylethanoids, lignans, flavonoids, and coumarins has been isolated from Fraxinus plant. These cookies do not store any personal information. All Rights Reserved! The ash tree was thought to have medicinal and mystical properties and the wood was burned to ward off evil spirits. This plant has no children Legal Status. With regard to ongoing investigations on Fraxinus plant’s biological applications further scientific experimentations and safety profiling are required to make understandings more clear and obvious in the treatment and prevention of various diseases. Medicinal Plant Common Ash. It is mandatory to procure user consent prior to running these cookies on your website. Zou, S. Lin, J.-G. Shi, and H.-B. Artemisinin, a potential antimalarial agent, was initially derived from Chinese medicinal herb Artemisia annua L. [20]. Cell signaling pathways are the main pillars behind cell communication as they are essential for the regulation of cell proliferation and survival. Metabolites and extracts from this plant have been found to possess variety of biological activities such as anticancer, anti-inflammatory, antioxidative, antimicrobial, hepatoprotective, antiallergic, skin regenerating, and diuretic [28, 29]. An alarming situation of resistance against antimalarial drugs leads to the requirement of affordable treatment from medicinal plants [97]. From 1981–2014, out of the 1562 drugs being approved, 1211 were small molecule approved drugs that are new chemical entities, which are nonsynthetic and obtained from natural products. Ku et al., “Syringin from stem bark of fraxinus rhynchophylla protects a, D.-L. Zhao, L.-B. Oleuropein, phenolic compound isolated from the leaves of Fraxinus rhynchophylla, showed anti-inflammatory effects on BV-2 microglial cells via suppression of proinflammatory response by effective inhibition of Drp1-dependent mitochondrial fission [58]. Particularly well-cited examples of natural products obtained from medicinal plants that have become prominent in modern pharmacotherapy as anticancer agents, include vinblastine and vincristine from Catharanthus roseus (Madagascar periwinkle), paclitaxel, and its derived compounds from Taxus species and camptothecin and its derivatives from Camptotheca acuminata Decne (Chinese tree) [5]. Inhibition of myeloperoxidase (an enzyme released by triggered granulocytes and reported to produce harmful agent hypochlorous acid) by extracts from Fraxinus excelsior along with Populus tremula recommends its usage as anti-inflammatory drug [61]. Nuzhenide and GI3, the novel compounds from Fraxinus excelsior L. seed extract (FXE), decrease the systolic blood pressure significantly in spontaneously hypertensive rats (SHR) and obese Zucker rats at a dose concentration of 200 mg/kg [32]. Committee on Herbal Medicinal Products (HMPC) Assessment report on Fraxinus excelsior L. and Fraxinus angustifolia Vahl, folium . Zhao, J. Liu et al., “Molecular mechanisms of casticin action: An update on its antitumor functions,”, A. Rasul, B. Yu, L. Zhong, M. Khan, H. Yang, and T. Ma, “Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinoma cells via simultaneous induction of apoptosis and autophagy,”, A. Rasul, M. Khan, B. Yu, T. Ma, and H. Yang, “Xanthoxyletin, a coumarin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells,”, A. Rasul, C. Ding, X. Li et al., “Dracorhodin perchlorate inhibits PI3K/Akt and NF-, A. Rasul, B. Yu, M. Khan et al., “Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways,”, M. K. Urban, “COX-2 specific inhibitors offer improved advantages over traditional NSAIDs,”, K.-J. Sign up here as a reviewer to help fast-track new submissions. This category only includes cookies that ensures basic functionalities and security features of the website. Fraxinus Excelsior. Fraxinus excelsior (Ash tree) male flowers developing and mature, East Ayrshire, Scotland.jpg 2 055 × 1 489; 672 KiB Fraxinus excelsior (Ash) flowers developing, East Ayrshire, Scotland.jpg 2 … Fraxini cortex, a traditional Chinese medicinal plant, possesses significant antidiarrheal properties having a notable effect on Cl(−) transport as simply the diarrhea is altered movement of Na+ and Cl− ions [108]. Most of the plants that have high percentage of polyphenolic compounds have been widely used in cosmetics for their antiaging properties [102]. The foliage of compound pinnate, dark green leaves contains 7-11 leaflets which turn rich shades of yellow in the fall. Evaluation of methanolic extracts from Fraxinus floribunda in rats at a dose concentration of 400 mg/kg/oral reveals its significant antinociceptive properties and its potential for relieving pain in pathological conditions such as inflammation [60].

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