AIDS 2001;15:215–22. False BMJ 2007;334:136. 3VJ/P+geV/LtzZraahFJeXOqOPrSSLbyOkltGEdFDfuzyPKoPhl0cY4SSwMt6Z2t7p89xLZpPFLc XYq7FXnWs+Y7rzrf+YvIuhRXVmlnGbXUfMkckSC3uHXmkawk+rIj8GjdlpT/AIbL4x4akfkwJuww PROCESS In order to manage our patients better, In addition, hepatotoxicity risk might be greater with the two drugs given together than with either drug given alone (91). The LTBI treatment guidelines committee members, who are the authors of this report, were nominated on the basis of their expertise in treatment of LTBI. Use of isoniazid chemoprophylaxis in renal transplant recipients. In: Kimberlin DW, Brady MT, Jackson MA, Long SS, eds. Our 2020 guidelines have also adopted the use of a fixed dose combination of Tenofovir alafenamide, Emtricitabine and Dolutegravir (TafED) to treat HIV positive children aged 6 years and above, and weighing 25kg or more. Jiménez-Fuentes MA, de Souza-Galvao ML, Mila Augé C, Solsona Peiró J, Altet-Gómez MN. Abbreviation: ref = referent. However, no clinical trial data were available directly comparing 9 months of isoniazid to placebo, 6 months of isoniazid, or 12 months of isoniazid. eGzl4O1tf3un61Z3Mda8UleOSahHX7PbrmHOQ8vubwE6vvJ+iaZxv9Gsbm0lSWOR7XSTEkbBdizW Potential drug interactions with rifampin and acquired drug resistance if TB disease is not adequately excluded also are important considerations (see previous section on 4 months of daily rifampin). The new guidelines, the RNTCP Technical and Operational Guidelines for Tuberculosis Control in India 2016, did not replace the previous guidance (the Standards of TB Care in India), but they provide updated recommendations. j/SWrabYHV9B8yRxxx3thOsywvbziLaSOXnUq/UYOICN1t1C1vT0vyX5Zu9B0yRNQ1GbVdVvZjd6 uxV2KuxV2KuxV2KuxV2KuxV2KpPrflXS9Vg1EFfql9qVm1hPqduEW5EDV+EOyt0qaVyUZkIIY9d+ ... PCS TB 2017 Guidelines. Reporting forms 6. The drug can cause hepatotoxicity and be associated with discontinuation because of adverse effects, although these effects are more common in adults than children (23,43). o5UeSI+EiKSy9e+VkFkisCuxV2KuxV2KuxV2KuxV2KuxV2KuxV2KuxV2KuxV2KuxVjfm7z1pXl3R Left untreated, 5% to 10% of patients with latent tuberculosis (TB) develop active TB. The GRADE evidence tables are provided (Table 1) (Supplementary Tables; https://stacks.cdc.gov/view/cdc/84235). Am J Respir Crit Care Med 2006;173:922–6. Local and state TB programs in the United States answer questions about diagnosing and treating persons with LTBI in their jurisdictions (http://www.tbcontrollers.orgexternal icon).. For these HIV-positive persons, the potential exists for a reduction in the incidence of TB disease and an increase in adverse effects with isoniazid therapy; however, the likelihood of these effects remains uncertain because of wide confidence intervals resulting from too few events. N6r5P85+WtLvktob/QrexuVU3EkOmXWhSFhXizCb1Y2pv9pl6/fjzgT3/O2yJZvLr2ka28VjpN7p The most recent comprehensive guidelines for treatment of LTBI in the United States were published in 2000 (8). Am J Respir Crit Care Med 2000;161:S221–47. Belknap R, Holland D, Feng PJ, et al. H�dUkT��a�����*#;�@�� � �x��X�(�,���� P��[��b�pL#�7�� <> Magenta 693 0 obj Mohammed A, Myer L, Ehrlich R, Wood R, Cilliers F, Maartens G. Randomised controlled trial of isoniazid preventive therapy in South African adults with advanced HIV disease. Estimated rate of reactivation of latent tuberculosis infection in the United States, overall and by population subgroup. Tuberculosis. zDzbrV7cN5vZo5Eazie5aS6lmdqLV4wsaCp5A+OZEhUuI8hyaxuK6pJ5he6GqR63o4CP5qm1Py5o Xt4/HpJMsQWn7K7HxzIxTEYmu5hKNndjHni38pC8tbHSoI9M8haXqyRXXoElr66t1M99NyckyLbw WNC1LSWk9JdRtZrRpacuInjaPlxqK05VpXDE0bQRb4OuLC70PW7jTNSgEV7YztDOpdkZJEPE8ZIz yzD2ZGBMoxAJ69WE9WSKJsPU0cOiuKgMAQGBU0O+4NCPpxVvFXYq7FXjf5u6Ve6n550XTJLGbzBD yceJCnvTK8nq9XRlHbZn2Us3Yq7FXYq7FXYq7FXYq7FXYqhtT1PT9LsJ9Q1G4S1srZS89xKQqKo8 Treatment of latent tuberculosis infection: an updated network meta-analysis. proof:pdf aNJR8QHNaxyChFeLUYZixlwm2wiw8gfzS2pP5H0HUEli/MPy9rdtbX1qEkZ2tUBjubkSbq0UsFJG GRADE evidence tables were prioritized according to the regimens, comparisons, and study populations that were deemed most clinically relevant to the United States. Shea KM, Kammerer JS, Winston CA, Navin TR, Horsburgh CR Jr. First Printing, 2020 ISBN: 978-621-95540-4-6 The mention (if any) ... on Tuberculosis, where countries committed to the goal of ending tuberculosis (TB) globally. 100.000000 In addition, a network meta-analysis evaluated regimens that had not been compared directly in clinical trials. They also make it absolutely clear that the guidance applies to the private sector as well as the public sector. OcLsxr6QU1TcVzJjilfED+hrMxyLKdEm/LnzX550fV/LF1aw6hoSXc99YpZvbXMouYhAGcusTUjM The two alternative treatment regimens are daily isoniazid for 6 or 9 months; isoniazid monotherapy is efficacious but has higher toxicity risk and lower treatment completion rates than shorter rifamycin-based regimens. S5cf8FF/zXj48O9fCl3Jr5b/AC1/PXy7qkeoaJpV5Y3ikD1EeIKwrXjIpfiy+IYUyMsuOQollGEx 2014-02-05T09:30:19+01:00 Results of the 2018 updated network meta-analysis are provided (Table 2); 63 studies of 16 regimens were evaluated (7,13,14,21–82). A Veterans Administration cooperative study XII. T1UibSNOtLjzJotyeIb6m0xMkEn/ABYs7fAf2q/IZXIcYBHPkkGtkN+TmmeVb7T38w6xYPF5ytJ5 Am Rev Respir Dis 1967;95:935–43. JPEG The ICN TB/MDR-TB Project aims to build global nursing capacity in the prevention, care and treatment of TB. CONTACT INFORMATION San Lazaro Compound, Tayuman, Sta. TB Trials Consortium iAdhere Study Team. If untreated, approximately 5%–10% of persons with LTBI progress to tuberculosis (TB) disease during their lifetime (3–5). /wAEM5PVwMe0OOW/puPvEf1u4wyvTUO+j8SgUljtJluJgb3WZ6PGnVYy4qtfFt+nbMGOSOGQnL97 C=100 M=87 Y=36 K=29 1 In the remainder, the infection remains in an ina… +YP5eeadHn1jzD5Guryztwhn1K0+p3Dw/s0knhuIpot6AAnfw2y8Y5RNCTAyBG4Zl+VdgITey2kv Email Alerts. Oox+XoJLvWW163uQtxpt/LCsMxtJY1aJZeJo77/aoCe+Y+Sr5U2RZDkEuxV2KuxV2KuxV2KuxV2K To update previous guidelines, the National Tuberculosis Controllers Association (NTCA) and CDC convened a committee to conduct a systematic literature review and make new recommendations for the most effective and least toxic regimens for treatment of LTBI among persons who live in the United States. TBqp+IEfaGRGfF5S72BFe5NPyt8lW7eWfL2reYtOEmu6cko0qe6HK6gs3djbRyHpySIigP2O1DXI Flow chart adapted from the Aurum Institute guideline: Managing TB in a new era of diagnostics, 2016. ased on the National Tuberculosis Management Guidelines 2014, Department of Health, South Africa Published March 2017 ASELINE EVALUATION OF T PATIENTS All patients: 1Vanderbilt University Medical Center, Nashville, Tennessee; 2National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Division of Tuberculosis Elimination, CDC, Atlanta, Georgia; 3Institute for Global Health, University College London, London, England; 4Denver Health and Hospital Authority, Denver, Colorado; 5Levine Children’s Hospital, Charlotte, North Carolina; 6Montreal Chest Institute and McGill International TB Centre, Montreal, Canada; 7Boston University Schools of Public Health and Medicine, Boston, Massachusetts; 8National Tuberculosis Controllers Association, Smyrna, Georgia; 9University of New Mexico Health Science Center and New Mexico Department of Health, Albuquerque, New Mexico. The WHO consolidated TB guidelines will gradually group all TB recommendations and will be complemented by matching modules of a consolidated operational handbook. This is a publication of the Federal Ministry of Health of Ethiopia. endobj Enferm Infecc Microbiol Clin 2007;25:300–4. 09vPbWCnV9HRtG/Mfy6QCJ7Rfhll4g/7rH7yNv5dq/DgAo8PQ7xKSevzXeTfyu1XStbu4PLWo3el WA6eOS8M1aOIIL81/MGraB5HvdR0pxBeCS3hW7ZQ4gWedImlKNs3EPt74cUQZUUTNB5n5803zRBN bIZJCgB0ZRB5lmeVMnYq7FXYq7FXYq7FXYq7FXYq7FXYq7FXYq7FXYq7FXYq8+1DyprnlW/1zX/J Comstock GW, Ferebee SH, Hammes LM.
It will help us if you say what assistive technology you use. o2mtCmo39tZPcHjAtxMkRkI7IHI5HfthESeS2lcXn3yxNqWn6fb3frzalcXVnbsingJ7FeU8bsac Enferm Infecc Microbiol Clin 2003;21:287–92. Spyridis NP, Spyridis PG, Gelesme A, et al. Chest 2003;124:2112–8. /Rk0zWLvQ/yv8x+TraLUNFWV7uX12toVtkUAXNi8ZE0jTvRnAPY8vFbJWLmDzYjfYhMfOHkXy3oO Treatment of latent tuberculosis infection: an updated network meta-analysis. 5k0+WNhTZl1WONGLA/ZinHz2yBn+P7GfD+P7X0F+UvmXV4Ik8t+YpZROELaRLfJ9WnkhQKBEEbks Hawken MP, Meme HK, Elliott LC, et al. Nephrol Dial Transplant 2010;25:634–7. uSKH+owNJFGa0eU/DEm388hVfpyUI8RAQTQt5R5dhs9c09T5P86RpfXkYfUvKGsk39n6z0eaFYro No potential conflicts of interest were disclosed. Falk A, Fuchs GF. <>stream 燎*?���hv��s���[G��~��:Kt���'��c���:�� ١k�e;���� XYq7FXYq7FXkH55+c9CGj32iyRakmp6e0VzYajaqVtY7wr+7SWdeS/CkvJ0dd16b0zJwQN3s15Ds Primary isoniazid prophylaxis against tuberculosis in HIV-exposed children. A conditional recommendation indicates that well-informed patients might make different choices regarding whether to choose the regimen (18,19). dirsVYV+bP5b2XnryxJYtxj1S15TaVdH9iWm6Mf5JKBW+g9stw5eA2wnDiD4mv7C80+9nsb2JoLu t/ecL3zLKlJrulUgDD4o4KjbwL9T7DbNZmzme3RzMeMR970zKGx2KuxV2KuxVKPN2l6NqnlnU7HW Prospective randomized control trial of isoniazid chemoprophylaxis during renal replacement therapy. 1BVlaKWXavIjauHmiOYbonvenZQzdirsVdirsVU7m3juLeSCQVSRSp+nv9GVZsUckDCXIhnjmYyB Johnson JL, Okwera A, Hom DL, et al. Magdorf K, Arizzi-Rusche AF, Geiter LJ, O’Brien RJ, Wahn U. The 2020 recommendations on drug resistant TB treatment are contained in the second module to be released under the rubric of WHO Consolidated Guidelines on Tuberculosis (Module 4: Treatment). Regimens of 6 or 9 months of daily isoniazid are alternative recommended regimens; 6 months daily is strongly recommended for HIV-negative adults and children of all ages and conditionally for HIV-positive adults and children of all ages and 9 months daily is conditionally recommended for adults and children of all ages, both HIV-negative and HIV-positive. 98.397797 Indian J Tuberc 1993;40:125–7. Med Clin (Barc) 2000;115:161–5. RR-1):1–11. This sixth edition of the national guidelines presents the most updated current guid-ance on programmatic and clinical management of patients with Tuberculosis and Leprosy in line with the global recommendations to hasten the efforts towards the control of TB epidemics in the country. In a noninferiority study of 3 months of weekly isoniazid plus rifapentine, the completion rate by self-administered therapy was inferior to the rate with direct observation but noninferior in the prespecified subpopulation from the United States (84). Latent TB infection treatment acceptance and completion in the United States and Canada. Strong GRADE recommendations required at least moderate evidence of effectiveness and that the desirable consequences outweighed the undesirable consequences in the majority of patients. This regimen, administered through directly observed therapy, had equivalent effectiveness and was not more toxic than the standard regimen of 9 months of daily isoniazid in adults and children aged >2 years (53,68,83). MMWR Recomm Rep 2020;69(No. iKa4mubNpp/KP5q+V7yztZpre4tJh8TxtBe2F5H8UUnBqMrDqKHcVFetKfVjLLaQQ3kvydrz302s Comstock GW. Drug interactions with weekly rifapentine are fewer than with rifampin and appear to be fewer than with rifabutin; therefore, weekly isoniazid and rifapentine could be considered when rifampin is contraindicated, although clinical data are limited (88). Ann Stat 1998;26:398–433. Andrews J, Guyatt G, Oxman AD, et al. epFEzorBKA0OYk6vbk3DknmQS7FXYqhdV0rTdW06fTdStku7G5XhPbyjkrDr94IqD1B3GEEg2FIf h1QSBuWNf8rVvr5QPL3k7W9SLmkU08KWFsw8RNcMNv8AY5Z4VcyGPF3BW8p+ePM2o+crzy5r+jwa N Engl J Med 2011;365:21–31. Nominations are required for post of President, General Secretary, Joint Secretary, Fin... 14th Biennial Chest Conference 2020. Tuberculosis Trials Consortium, the AIDS Clinical Trials Group for the PREVENT TB Trial (TBTC Study 26ACTG 5259) The investigators of the TB Trials Consortium and the AIDS Clinical Trials Group for the PREVENT TB Trial are listed in the Supplement, item 17. tWwiCoP2UuZwXT/YpTImcRyF+9NFnOi6Umk6Xb6clxcXa268Rc3chmnepJrJId2O+UyNm2YDAfzC Menzies D, Long R, Trajman A, et al. Induction of influx and efflux transporters and cytochrome P450 3A4 in primary human hepatocytes by rifampin, rifabutin, and rifapentine. [Short-course isoniazid and rifampin compared with isoniazid for latent tuberculosis infection: a randomized clinical trial]. In these current guidelines, application of GRADE criteria resulted in a strong recommendation for 6 months of isoniazid as an alternative for those persons unable to take a shorter preferred regimen (e.g., due to drug intolerability or drug-drug interactions), particularly in HIV-negative persons. MsbRg7dhyww9JHkp3eS6lc+Z9X/JrUvKEnl3U7LW9K0uKCaWSAC2nNm8asttIrH1TJGhYBV/hXJA XYq7FXYq7FXYq7FXYq+Svzs/ODVPNer3Wg6HctF5atm9JlRghu5EPxSNuCY+Q+BfYMd+mxwYREWe PLoS One 2015;10:e0140881. Most infected persons are asymptomatic and classified as having latent tuberculosis infection (LTBI). Adverse events with 4 months of rifampin therapy or 9 months of isoniazid therapy for latent tuberculosis infection: a randomized trial. 8u6fPqTScGDKFmLNxbmoNa5fCFbiJ+LWZX1e86ddC80+1uwrqLiGOULKhjkHNQ1HjO6NvuvbMQii zZnDNDMnqQyLJGSQHQhhVSVYVHgRQ5UyX4q7FXYq7FXYq7FXYq7FXYq7FULqeq6Zpdm97qV3DZWk 4. New regimens to prevent tuberculosis in adults with HIV infection. Potential disadvantages of this regimen include cost of medications that are greater than most alternatives, potential added costs if provided by directly observed therapy (with treatment completion being highest with directly observed therapy, although self-administered therapy is an approved option) (85), the need to take numerous pills simultaneously (10 pills once weekly compared with two or three pills daily for other regimens for most adults), and the association with a systemic drug reaction or influenza-like syndrome that can include syncope and hypotension. Tuber Lung Dis 1996;77:239–43. To reduce by at least 5% per year by 2020 the prevalence of MDR-TB among TB patients who have never received any TB treatment. Isoniazid reduces the risk for developing TB disease in persons with a positive TST, including HIV-negative adults and children (7,23,28,43,47,73), HIV-positive adults (27,38,42,46,60,72), and presumably also HIV-positive children. (They should get information on this from the local multidisciplinary TB team.) �� [�J���YG�w�ϭ2�Hj'�����0)��Pk���=���寀{���*�?E�X/��Bޑf���(��@ާG���������dW�J9�h���4&��Je�$��z4��~�2�J~��!����h���1Ei�3lB�����DO�pC�Q�z�H�8��$%TίHB�W�I|��_�/_~d����� /��m�x��\��aO��1w��d�N��ծ{C�����ޏ� �l|߅Ze^K��6��w@�0s2��|����UZZ������w4%�p�� �G�ɐS�v]Ѧ�u�'RToIYb����tH����L� ^���0x���`����]��;Kؔ��#B�h��F�*�N :�B���ժ�ʜn�u��л'�?��\�I��[:�'�+�~興⨤糥����gdc`Q%�b���b����-K�f� N2KuxV2KuxV2KrJ4Ip4JIJl5RSqUkXcVVhQjb2xVJrXyboUPlKLypNE15o0UC2piuGqzxL0DMvDc Recommendations were formulated on the basis of the following considerations: the balance of desirable consequences of the intervention (benefits) and undesirable consequences (regimen complexity, adverse effects, and cost), the quality of evidence, patient values and preferences, and feasibility (19). Uganda-Case Western Reserve University Research Collaboration. AIDS 2015;29:351–9. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. dwSTaXos1xHZaetxbgiaWaQD1ZiqSKeG23cgkZk4TUSeTXMWU+tPJX5k30EdtqfmK28vaZHxVNK8 If you notice ommissions or errors, please tell us. Third, these guidelines focus on treatment regimens for persons with LTBI living in countries with low TB disease incidence. Study characteristics, types of participants, interventions, the outcomes measured, and results were extracted from each study. Guidelines for the Treatment of Latent Tuberculosis Infection: Recommendations from the National Tuberculosis Controllers Association and CDC, 2020 [2020] Update of Recommendations for Use of Once-Weekly Isoniazid-Rifapentine Regimen to Treat Latent Mycobacterium tuberculosis Infection [2018] U.S. TB control guidelines by topic. Network inconsistency, which can arise if indirect comparisons conflict with direct pairwise estimates, was assessed by comparison with standard meta-analysis and by using the omnibus test for consistency (17). Yellow vfmhcfU9MvvMMfonzbqQg8r6ZDH/AKQlmxVEmnJYAr0kYgbBu/QSli510G6BPv6vRo5YpOXpur8G The committee discussed evidence during face-to-face meetings and teleconferences. pd7GQHXjJFJGw4srA1HiGU/I4kEFebzLXfKl55JtrxbKyfX/AMt70N+mPLTfvJrJXNXns67tGv2v A controlled trial of community-wide isoniazid prophylaxis in Alaska. 5Z7kDkmEdt3o+UM3Yq7FXYq7FXYq7FXYq7FXYq7FXYq7FXYq7FXYq7FXYq7FXYq838+eUbHR7S68 We have classified the guidelines into several categories, but this division is sometimes arbitrary. Gordin FM, Cohn DL, Matts JP, et al. endobj s/yWGgX3lO/0lBeajplxJca9fSTyI1y7RP8AEsTM0dTI/XqB3OWHPdgsRCqTr8mote0ry7H5b1rQ Transmission of tuberculosis to close contacts of patients with multidrug-resistant tuberculosis. Comstock GW, Baum C, Snider DE Jr. Isoniazid prophylaxis among Alaskan Eskimos: a final report of the bethel isoniazid studies. endobj Itasca, IL: American Academy of Pediatrics; 2018:829–53).†† The American Academy of Pediatrics recommends an isoniazid dosage of 10–15 mg/kg for the daily regimen and 20–30 mg/kg for the twice-weekly regimen. 1 Menzies D, Adjobimey M, Ruslami R, et al. Isoniazid plus antiretroviral therapy to prevent tuberculosis: a randomised double-blind, placebo-controlled trial. RbRNv6CH+b+dvHYbCp1mfNxGhyc3Hj4R5vU8x2x2KuxV2KuxV2KuxV2KuxVRvbuCzs57yc8YLaN5 Early detection provides an opportunity to promote the health of affected The global burden of latent tuberculosis infection: a re-estimation using mathematical modelling. CDC twenty four seven. Since the last guidelines, published in 2000, several treatment regimens have been studied. wpo8bEV4SIfiRvYjNfOBiaLlAg8kTq+u6Vo8McuoT+kJn9KCNVeSWWQivCOKMPI7UFaKpwCJPJNr Tuberculosis Epidemiologic Studies Consortium. TEMPRANO ANRS 12136 Study Group. xV2KuxV2KuxV2KuxV2KvE/z0/I69813sXmDy0kQ1ghYtQtpGEYnVdkkDH4eaDY1O6+4ocrT5+HY8 9K1jTNWtPrWnXC3EIZo3IqGR12ZHRgGRl7qwBxII5qjMCuxV2KuxV2KuxV2KvG/KF35h8lW19ov+ endstream * The results from the 2017 analysis were published, citing all primary studies included in the analysis (Zenner D, Beer N, Harris RJ, Lipman MC, Stagg HR, van der Werf MJ. 694 0 obj LzzEgFuUlShawd4+NHXoD1bZvtUGZWMgDiHxDVIXt8mFweb9d0yWPzF5jsXvtNuw2hecmjShkRKx 707 0 obj [Compliance, tolerance and effectiveness of a short chemoprophylaxis regimen for the treatment of tuberculosis]. Int J Tuberc Lung Dis 2007;11:1114–20. q7FXYq7FXYq7FXYq7FUBr2sWGj6VcahfXcFjBEtPrNyaRK7HinLcEgsRsDhjEk0EE08O0784fL2l /vy2leFvvQrmSYg82kSI5M20n8//AM1tNVY11o3cSmvC7iimJ+cjL6n/AA2VHTwPRsGaTMNM/wCc [Compliance and tolerance of new antitubercular short-term chemopreventive regimens in childhood—a pilot project]. However, direct, pairwise meta-analysis was the preferred method; the results of the network analysis are presented in this report only if no direct comparisons were available. (��&� jڥŭ� �6$�'���[%�?z��wy��y�����)g'��i��K#�GO_�ߖ����k�u�IY�I�� ��>����|ƛrw)q���BƉ.O�M"t�E��Դa���Eɺ�ZuLQn�63W�,k�N���'�i���E[����s���\�>���z�:=W���kS� T�MV�铒��I��.E�2=K�W��U/�X����#� K����I�tmn E���hj���BQ�@S�45��>���2j9E���5NTC��(5i�D�(/*�*���h������i���n�T��2��\��]�Ϝ���lg�ʺ�Ilk��q���r9N m��'(�'``Й�c��f8"k�b%1�V^Yf�n��Kv���.�K%jZ1b!��A�DH�X�M�dԨ잖Z��Z��9k'�EWt� k�S�+��~���`�/@��mxu�Gb8�;��~��+��R���x :���SZmF{�t��]��`������T�\U��R���7�:�`�ްtG�1q�����v�4C�Y!�����0������_m�f���ʛ�����_s����}���ȏJ�oPa�/w�}-|{'s~��>B�a��,R�%�������ix���m�d]U�����1���� ���� ���A&?mi�'N�1@C(�x .0�z{iN�(��2Q {,i��4������\%?h��X3��x��w�X����02�����Y�?������,�h���ë��m�����Y�M�NĚxb Y��_�]��O��~���(���l�����(�VQ�M%���aL@�4d%~ؤ�6>a����[�� Bull World Health Organ 1966;35:509–26. 89RaRrogsvOtjpN5bxosuhXdk14HkY8wzvAROnJHXYdhXvl2PHY3FsJS83mHmSW580zvNJ5Lm1C9 ); the 2018 update includes data subsequently published (Diallo T, Adjobimey M, Ruslami R, et al. The GECMEI Group. Zhonghua Yi Xue Za Zhi 2014;94:3579–82. Sánchez-Arcilla I, Vílchez JM, García de la Torre M, Fernández X, Noguerado A. uxV2KsA/M7zn508oy22qWGk22q+V+HDVKu8dxDIWIDlxzVYiCN+BoetBl2KEZbE7sJSIefr5k0bS
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